Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation
نویسندگان
چکیده
منابع مشابه
Activation of T lymphocytes in atherosclerotic plaques.
OBJECTIVE To decipher the immunologic mechanisms of plaque maturation and rupture, it is necessary to analyze the phenotypes and distribution of individual lymphocytes that migrate to the plaques, as well as their activation at different stages of plaque formation. METHODS AND RESULTS We developed a protocol to isolate plaque-residing immune cells and analyze their status using polychromatic ...
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Following occupancy of the T cell receptor by antigen, T cell proliferation and lymphokine production are determined by a second costimulatory signal delivered by a ligand expressed on antigen presenting cells. The human B cell activation antigen B7, which is expressed on antigen presenting cells including activated B cells and gamma interferon treated monocytes, has been shown to deliver such ...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 1997
ISSN: 0021-9150
DOI: 10.1016/s0021-9150(97)00135-4